MEDICAMENTS AND METHODS FOR PROMOTING WOUND CONTRACTION

摘要

Provided are antagonists of FXR activity for use as medicament for the prevention, reduction or inhibition of scarring. This use may preferably be to prevent, reduce or inhibit scarring formed on healing of wounds. The invention also provides corresponding methods of treatment. Preferred antagonists of FXR activity include guggulsterone (Z); guggulsterone (E); a scalarane; 80-574; and a 5a-bile alcohol. In advantageous embodiments, up to 32 µM of the antagonist of FXR activity may be provided per linear cm of wound, or cm² of a wound or fibrotic disorder, over a 24 hour period in order to inhibit scarring.