IMIDAZO[1',5':1,6] PYRIDO[3,4-B]INDOLES DERIVATIVES AND THERAPEUTICAL USE THEREOF

摘要

The present invention relates to a compound of the formula (I) in which: R1 is a hydrogen atom or a C<SUB>1</SUB>- C<SUB>6</SUB> alkoxy group; R2 is a hydrogen atom or a C<SUB>1</SUB>- C<SUB>6</SUB> alkyl group optionally substituted by a hydroxy group; R3 is a hydrogen atom, a C<SUB>1</SUB>- C<SUB>6</SUB> alkyl group optionally substituted by a hydroxy group, or an aryl group optionally substituted by a sulfonic group; the pointed line of the cycle is absent and ---R 6 is === O or __ R 6 in which R6 is a hydrogen atom, a hydroxy group or a C<SUB>1</SUB>- C<SUB>6</SUB> alkyl group; or the pointed line of the cycle is a bond and ---R 6 is R6 in which R6 is a hydrogen atom, a hydroxy group or a C<SUB>1</SUB>- C<SUB>6</SUB> alkyl group; ---R 4 is ===x in which X is a hydrogen or sulphur atom or - R 4 in which R4 is a hydrogen atom or a C<SUB>1</SUB>- C<SUB>6</SUB> alkyl group; R5 is a C<SUB>1</SUB>- C<SUB>6</SUB> alkyl group, a C<SUB>2</SUB>-C<SUB>6</SUB> alkenyl group, a C<SUB>3</SUB>-C<SUB>12</SUB> cycloalkyl group, an arl group, an arylcarbonyl group or an aralkyl group, the aryl group being optionally substituted by a halogen atom, a C<SUB>1</SUB>- C<SUB>6</SUB> alkoxy group or a C<SUB>1</SUB>- C<SUB>6</SUB> alkyl group optionally substituted by one or more halogen atoms. The invention also relates to the use of the compound as a drug, to a method for preparing the same and to the use thereof in pharmaceutical and/or cosmetic compositions, in particular for regulating the waking-sleeping circadian cycle.