METHOD OF ABROGATING GRAFT VERSUS HOST DISEASE VIA INDUCED SHIP DEFICIENCY

摘要

Disclosed herein is method of treatment method wherein SHIP-deficiency is induced. The induction of SHIP deficiency leads to a rapid and significant expansion of myeloid suppressor cells (MySC) in peripheral lymphoid tissues. Consistent with expansion of MySC, splenocytes and LN cells from hosts with induced SHIP deficiency are significantly compromised in their ability to prime allogeneic T cell responses. These results demonstrate that SHIP regulates homeostatic signals for these immunoregulatory cells in adult physiology. Consistent with these findings, induction of SHIP deficiency prior to receiving a T cell replete BM graft abrogates acute GVHD. These findings indicate strategies that target SHIP could increase the efficacy and utility of allogeneic BMT and thereby provide a curative therapy for a wide spectrum of human diseases.