METHOD OF DETERMINING THE WEIGHT OF THE COATING TO BE APPLIED TO FORM A CONTROLLED RELEASE DOSAGE FORM

摘要

A method of coating spherical particles of a beta blocker compound which is based on (a) determining the surface area of a weighed sample of said sph erical particles; (b) determining the weight of coating material per surface area unit of spherical particles that will provide a desired release profil e for said beta-blocker; (c) determining the surface area of a subsequent ba tch of spherical particles containing the same beta; (d) coating the subsequ ent batch of spherical particles with the coating applied in step (b) to pro vide a coating having substantially the same weight of coating material per surface area unit of spherical particles as determined in step (b).