| 发明名称 |
EXPRESSION OF PACE IN HOST CELL AND METHOD OF USE THEREOF |
| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide a composition and method for endopeptidase production. <P>SOLUTION: There are provided the composition and the method for endopeptidase production and for enhanced efficiencies of processing heterologous precursor polypeptide to mature polypeptide, including protein requiring gamma-carboxylation for biological activity. These composition and method utilize recombinant PACE, a mammalian endopeptidase that is specific for dibasic amino acid sites. <P>COPYRIGHT: (C)2008,JPO&INPIT |
| 申请公布号 |
JP2008194050(A) |
申请公布日期 |
2008.08.28 |
| 申请号 |
JP20080066877 |
申请日期 |
2008.03.14 |
| 申请人 |
GENETICS INST LLC;NOVARTIS VACCINES & DIAGNOSTICS INC |
发明人 |
BARR PHILIP J;BRAKE ANTHONY J;KAUFMAN RANDAL J;TEKAMP-OLSON PATRICIA;WASLEY LOUISE;WONG POLLY A |
| 分类号 |
C12N5/10;C12N15/09;C07K14/755;C12N9/50;C12N9/64;C12N15/57;C12P21/02 |
主分类号 |
C12N5/10 |
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