A SET OF SEQUENCES FOR TARGETING EXPRESSION AND CONTROL OF THE POST-TRANSLATIONNAL MODIFICATIONS OF A RECOMBINANT POLYPEPTIDE

摘要

The present invention provides new tools useful for controlling the post-translational modifications of recombinant polypeptides. These tools are particular signal peptides allowing the targeting of recombinant polypeptides during their synthesis in a host cell to specific sub-cellular compartments and a specific designing of said recombinant polypeptides within said sub-cellular compartments. These signal peptides are SEQ IDn-1 to SEQ IDn -31 disclosed herein. The present invention allows advantageously, for example, to increase the yield of production of a recombinant polypeptides, to prevent immunogenicity of recombinant polypeptides and to obtain therapeutically active recombinant polypeptides that are the exact copy of their natural counterpart. This invention relates particularly to the field of reorientation of plants made pharmaceuticals (PMP).