| 摘要 |
Chimeric fusion proteins comprising Neisseria transferrin binding proteins (Tbps) from, for example, N. gonorrhoeae and/or N. meningitidis are provided. The fusion proteins elicit an antibody response in the mucosa of the urogenital and/or oropharynx tract, as well as in the serum. The resulting serum antibodies are cross-bactericidal against heterologous bacterial strains. The chimeric proteins also comprise a mucosal adjuvant such as a toxin subunit, e.g. the B subunit of cholera toxin or of Escherichia coli heat labile toxin II. Methods of inhibiting the growth of Neisseria species on mucosal surfaces of a mammal by either administering the fusion proteins of the invention, or antibodies directed to the fusion proteins of the invention, to the mammal.
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