The invention provides methods for predicting or determining the response of a mammalian tumor to a chemotherapeutic agent and for treating a mammalian tumor comprising detecting and quantifying the SPARC protein or RNA in a sample isolated from the mammal. The invention further provides kit for predicting the response of a mammalian tumor to a chemotherapeutic agent, comprising a means for the isolation of protein or RNA from the tumor, a SPARC protein or RNA detection and quantification means, control RNAs, and rules for predicting the response of the tumor based on the level of SPARC protein or RNA in tumor.
申请公布号
WO2008060651(A3)
申请公布日期
2008.08.28
申请号
WO2007US65486
申请日期
2007.03.29
申请人
ABRAXIS BIOSCIENCE, INC.;TRIEU, VUONG;DESAI, NEIL, P.;SOON-SHIONG, PATRICK