FUNCTIONALIZED DRUGS AND POLYMERS DERIVED THEREFROM

摘要

Compounds selected from: where DRUG-OH, DRUG-COOH and DRUG-NH2 are biologically active compounds; each X is independently selected from—CH2COO—(glycolic acid moiety),—CH(CH3)COO—(lactic acid moiety),—CH2CH2OCH2COO—(dioxanone moiety),—CH2CH2CH2CH2CH2COO—(caprolactone moiety),—(CH2)yCOO—, where y is 2-4 or 6-24 and—(CH2CH2O)zCH2C—, where z is 2-24; each Y is independently selected from—COCH2O—(glycolic ester moiety),—COCH(CH3)O—(lactic ester moiety),—COCH2OCH2CH2O—(dioxanone ester moiety),—COCH2CH2CH2CH2CH2O—(caprolactone ester moiety),—CO(CH2)mO—, where m is 2-4 or 6-24 and—COCH2O(CH2CH2O)n—where n is between 2-24; R′is hydrogen, benzyl or an alkyl group, the alkyl group being either straight-chained or branched; and p is 1-6. Multi-functional compounds and drug dimers, oligomers and polymers are also disclosed.