发明名称 |
Screening for peptides inhibiting PP1c binding to BcI-2, BCL-XL and BCL-W proteins |
摘要 |
<p>The invention relates to methods for identifying novel PP1-interacting polypeptides and proteins, compounds which are able to inhibit the binding of PP1c to certain factors naturally interacting with it, especially proteins of the Bcl-2 family (such as Bcl-x L and Bcl-w), and pharmaceutical compositions comprising the same. The invention is based on the identification of a new PP1- binding motif having the sequence FXX[RK]X[RK], wherein X is any amino acid.</p> |
申请公布号 |
EP1933150(A1) |
申请公布日期 |
2008.06.18 |
申请号 |
EP20070025179 |
申请日期 |
2003.05.06 |
申请人 |
INSTITUT PASTEUR |
发明人 |
GARCIA, ALPHONSE;CAYLA, XAVIER;REBOLLO, ANGELITA |
分类号 |
G01N33/68;A61K38/00;A61K38/17;A61K48/00;C07K7/06;C07K7/08;C07K14/47;C07K16/18;C07K16/44;C12N9/16;C12N15/11;C40B30/04;G01N33/50 |
主分类号 |
G01N33/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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