| 摘要 |
The present invention relates to non-steroidal progestins of the general formula (I) wherein R<SUB>1 </SUB>and R<SUB>2 </SUB>are independently of each other -H or -F, R<SUB>3 </SUB>is -CH<SUB>3 </SUB>or -CF<SUB>3</SUB>, and Ar is or a pharmaceutically acceptable derivative or analogue thereof. These progestins are suitable for selectively modulating progesterone receptor mediated effects in different target tissues, particularly in uterine tissue versus breast tissue. Therefore, the progestins of the present invention, optionally in combination with estrogens, may be used for contraception (in particular in estrogen-free oral contraceptives), hormone replacement therapy and the treatment of gynecological disorders. The present invention furthermore relates to methods for selectively modulating progesterone receptor mediated effects in different target tissues or organs.
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