Solid composition, useful e.g. for preparing tablet of candesartan cilexetil for treating hypertension, comprises candesartan cilexetil and stabilizing agent comprising e.g. esters of saturated fatty acids and monohydroxy alcohols

摘要

Solid pharmaceutical composition (I) for oral use comprises: a candesartan cilexetil; and a stabilizing agent comprising esters of saturated fatty acids and monohydroxy alcohols, esters of hydroxycarboxylic acids and monohydroxy alcohols, ethers of 1-4 carbon monohydroxy alcohols and 2-9 carbon polyhydroxy alcohols, saturated fatty acid alkaline salts or panthenol. Independent claims are included for: (1) a process for preparing (I) comprising mixing candesartan cilexetil with the stabilizing agent, and molding the mixture; and (2) a tablet of candesartan cilexetil comprising (I) to provide unit dose of candesartan cilexetil, and at least one auxiliary agent. ACTIVITY : Hypotensive. MECHANISM OF ACTION : Angiotensin II receptor antagonist.