New naphthoquinone compounds useful as pro-apoptotic and/or anti-proliferative agent to treat cancers

摘要

1,4-Naphthoquinone compounds (I) and their salts are new. 1,4-Naphthoquinone compounds of formula (I) and their salts are new. R 1-R 51-18C alkyl, 2-18C alkenyl, 2-18C alkynyl, aryl, arylalkyl or alkylaryl (all optionally substituted by at least 1 amino, acid, acid derivative, alkoxy, aryl or OH), H, halo, OH (optionally substituted) or nitro, or R 2 + R 3, R 3 + R 4, R 5 + R 5heterocyclyl (optionally substituted); X : a divalent group such as linear, branched or cyclic alkyl, alkenyl or alkynyl (all optionally interrupted by a heteroatom and all optionally substituted); Y 1H or a protecting group; and Z : natural or synthetic D- or L-amino acid residue. [Image] ACTIVITY : Cytostatic. MECHANISM OF ACTION : None given.