O-SUBSTITUTED HYDROXYARYL DERIVATIVES

摘要

Drugs having inhibitory activity against NF-&kgr;B activation, containing as the active ingredient substances selected from the group consisting of compounds represented by the general formula (I), pharmacologically acceptable salts thereof, and hydrates and solvates of both:wherein X is a connecting group whose main chain has two to five atoms and which may be substituted;A is optionally substituted acyl (exclusive of unsubstituted acetyl and unsubstituted acryloyl) or optionally substituted C-alkyl, or alternatively A and X may be united to form a ring structure which may be substituted;E is optionally substituted aryl or optionally substituted heteroaryl; andZ is arene which may have a substituent in addition to the groups represented by the general formulae: -O-A (wherein A is as defined above) and -X-E (wherein X and E are each as defined above) or heteroarene which may have a substituent in addition to the groups represented by the general formulae: -O-A (wherein A is as defined above) and -X-E (wherein X and E are each as defined above).