| 摘要 |
This invention is directed toward methods kits and compositions pertaining to the use of high affinity probes for diagnostic applications. The invention is further directed toward the use of the high affinity probes for the detection of clinically important human papillomavirus (HPV) strains. High affinity probes enable rapid diagnostic assays and supply sufficient hybridization specificity to discriminate closely related HPV strains. Examples of high-affinity probes are provided which are specifically directed towards the detection of the E6 and E7 regions, and splice variants thereof of HPV mRNA.
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