Pyrazolo [3,4-B] pyridine Compounds and Their Use as Phosphodiesterase Inhibitors

摘要

The invention provides pyrazolo[3,4-b]pyridine compounds of formula (I) having a -C(O)-NH-C(R⁴)(R⁵)-aryl substituent at the 5-position of the pyrazolo[3,4-b]pyridine ring system wherein at least one of R⁴ and R⁵ is not a hydrogen atom (H) compound or a salt thereof: wherein Ar has the sub-formula (x) or (z). These compounds are useful as inhibitors of PDE4.