| 摘要 |
PROBLEM TO BE SOLVED: To provide an effective method for producing an erythromycin derivative. SOLUTION: The invention relates to the method for effectively preparing a high quality erythromycin derivative by the following steps. Carbamating a compound represented by formula (I) in the presence of a cyclic ether or a carboxylic ester, (wherein R<SB>1</SB>represents a hydrogen atom or a lower alkyl group), removing all carbamate groups from this compound, alkylating the nitrogen atom at the 3'-position of the desosamine ring in the resulting compound to give the compound represented by formula (II), (wherein R<SB>1</SB>represents a hydrogen atom or a lower alkyl group, and R<SB>2</SB>represents a lower alkyl group), changing th resulting compound to give a fumarate salt of a compound represented by formula (II). COPYRIGHT: (C)2007,JPO&INPIT
|
