2-ARYL-2-FLUOROALKANOIC ACID, ESTER THEREOF, AND PROCESSES FOR PRODUCING THESE

摘要

A process shown by the following scheme which is for producing a 2-aryl-2-fluoroalkanoic acid ester in a high yield through a small number of steps; and a novel 2-aryl-2-fluoroalkanoic acid compound produced by the process. The compound produced, which has a fluorine atom introduced into the chiral center, heightens the pharmacological activity of an antipyretic/analgesic/anti-inflammatory agent, reduces the side effects of the agent, and is useful as a novel optical resolver, a raw material for a liquid crystal, etc. (In the formula (1), Ar means optionally substituted aryl, etc.; R^a means a carboxy-protecting group; and R¹ means optionally substituted alkyl.).