| 摘要 |
The invention relates to a method for producing a concentrated solution consisting of biological substances such as, e.g. viruses, virus particles, antibodies and proteins, while using a bioreactor system having a filtering unit provided in the form of a membrane or of a membrane system. The yield and the level of the concentration of the unstable biological products are positively influenced by integrating a parameter control unit for depicting different levels of one or more process parameters during the production process. The bioreactor and filtering unit are connected to form a bioreactor system in which, during filtration, the unstable biological substances are cooled and retained in the membrane system, and the filtrate is optionally returned to the bioreactor. |
