发明名称 |
Glutamic acid decarboxylase (GAD) based delivery system |
摘要 |
The invention provide methods and compositions for localized delivery of a vector comprising a therapeutic agent to a specific region of the brain that is overstimulated in neurodegenerative diseases. In particular, the invention provides methods and compositions used to deliver an adeno-associated virus vector (AAV) comprising a nucleotide sequence encoding glutamic acid decarboxylase (GAD) to cells in the subthalmic nucleus of the basal ganglia, mesaphilia and thalmus.
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申请公布号 |
US2006099179(A1) |
申请公布日期 |
2006.05.11 |
申请号 |
US20040802417 |
申请日期 |
2004.03.16 |
申请人 |
NEUROLOGIX, INC. |
发明人 |
DURING MATTHEW;KAPLITT MICHAEL |
分类号 |
A61K48/00;A61K9/127;A61K38/51;A61P25/28;C12N15/864 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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