摘要 |
The present invention is drawn to adhesive peel-forming formulations for dermal delivery of a drug. The formulation can include a drug, a solvent vehicle, and a peel-forming agent. The solvent vehicle can include a volatile solvent system having one or more volatile solvent, and a non-volatile solvent system having one or more non-volatile solvent, wherein the non-volatile solvent system has a solubility for the drug that is within a window of operable solubility for the drug such that the drug can be delivered at therapeutically effective rates over a sustained period of time. The formulation can have a viscosity suitable for application to a skin surface prior to evaporation of the volatile solvents system. When applied to the skin, the formulation can form a solidified peelable layer after at least a portion of the volatile solvent system is evaporated. |
申请人 |
ZARS, INC.;ZHANG, JIE;WARNER, KEVIN, S.;ASHBURN, MICHAEL, A.;RIGBY, LARRY, D.;NIU, SUYI |
发明人 |
ZHANG, JIE;WARNER, KEVIN, S.;ASHBURN, MICHAEL, A.;RIGBY, LARRY, D.;NIU, SUYI |