| 摘要 |
A bioreactor ( 200 ) for cultivating living cells in a liquid medium. In one embodiment, the bioreactor ( 200 ) has a substrate ( 230 ) having a first surface and an opposite second surface, defining a channel ( 202 ) therein, and a plurality of chambers ( 204 ) formed in the substrate, wherein each of the plurality of chambers ( 204 ) is adapted for receiving cells in a liquid medium and formed with an open end ( 262 ), an opposite closed end ( 264 ) and side walls, the open end ( 262 ) and the closed end ( 264 ) defining a depth, d, therebetween for the corresponding chamber ( 206 ), the sidewalls defining a width, w, therebetween for the corresponding chamber ( 206 ). As such formed, each chamber ( 206 ) is in fluid communication with the channel ( 202 ) through the open end of the chamber ( 206 ), and at least two of the plurality of chambers ( 206 ) have depths or widths the same or different form each other.
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