Micellar preparation containing sparingly water-soluble anticancer agent and novel block copolymer

摘要

A novel micellar preparation in which the solubility of a sparingly water-soluble anticancer agent has been heightened and which after intravenous administration, enables a high blood concentration to be maintained. The preparation has high medicinal activity and/or is reduced in side effects. The micellar preparation is formed from a block copolymer represented by the following general formula (1): [wherein R1 represents hydrogen or C_1-5 alkyl; R2 represents C_1-5 alkylene; R3 represents methylene or ethylene; R4 represents hydrogen or C_1-4 acyl; R5 represents hydroxyl, optionally substituted aryl C_2-8 alkoxyl, substituted C_1-4 alkylamino, or amino having a residue of either an amino acid or a peptide derivative; n is an integer of 5 to 1,000; m is an integer of 2 to 300; and x is an integer of 1 to 300; provided that the proportion of hydroxy in the R5's is 0 to 99% and x is not larger than m] and a sparingly water-soluble anticancer agent.