METHOD OF MODIFYING BLOOD CONTACT MATERIAL AND BLOOD CONTACT MATERIAL INHIBITED FROM ACTIVATING GRANULOCYTE

摘要

A method of modifying a blood contact material. The granulocyte-activating function of a blood contact material to be used in that part of a medical instrument which comes into contact with blood can be reduced by the method. The method of modifying a blood contact material is characterized by fixing a tryptophan derivative and a polyanionic compound to the blood contact material. The material thus modified is far more reduced in the function of activating granulocytes upon contact with blood than the original blood contact material. An example of the tryptophan derivative is tryptophan. An example of the polyanionic compound is dextran sulfate.