| 摘要 |
Disclosed are compositions and methods that can be used to identify antiviral compounds. The methods can be carried out by exposing a cell that expresses a host factor to a candidate compound. If the expression or activity of the host factor, which is a protein we identified by virtue of its influence on the endogenous retrovirus-like Ty1 element in yeast, is inhibited, the candidate compound is a potential antiviral agent. Such agents can be further tested, if desired, by determining whether they inhibit the ability of the virus to infect a cell or replicate within it.
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