The tablets, compositions and methods of the present invention, comprising a carbonate salt of an aliphatic amine polymer and s monovalent anion can<SUB/>prevent or ameliorate acidosis, in particular acidosis in patients with renal disease. The tablets and compositions of the present invention maintain a disintegration time of no greater than 30 minutes at 37°C and at pH of at least 1 for a period of at least ten weeks at 60 °C. Furthermore, the tablets are stable for extended periods of time without the need for specialized storage conditions.
申请公布号
WO2006050315(A2)
申请公布日期
2006.05.11
申请号
WO2005US39366
申请日期
2005.11.01
申请人
GENZYME CORPORATION;BHAGAT, HITESH;GOLDBERG, JEFFERY, MARC;HARIANAWALA, ABIZER;BRENNER, LOUIS
发明人
BHAGAT, HITESH;GOLDBERG, JEFFERY, MARC;HARIANAWALA, ABIZER;BRENNER, LOUIS