| 摘要 |
PROBLEM TO BE SOLVED: To provide an amide derivative useful for preventing and/or treating C5a-concerned diseases and the like, its salt allowable in pharmaceutical preparation, its hydrate and solvate, and their medicinal application. SOLUTION: There are provided an amide derivative represented by formula (1), its pharmaceutically allowable salt, and its hydrate and solvate. These compounds of this invention have a C5a acceptor antagonism, are useful as a prophylactic and/or a therapeutic agent against C5a-concerned diseases and as an anti-inflammatory agent, and are also useful as a prophylactic and/or a therapeutic agent against infectious diseases by bacteria or viruses penetrating through a C5a receptor. COPYRIGHT: (C)2006,JPO&NCIPI
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