| 摘要 |
A process for the preparation of 2Æ-deoxy-2Æ-halo-beta-L arabinofuranosyl nucleoside of formula (I), particularly 2Æ-deoxy-2Æ-halo-beta-L arabinofuranosyl thymine (L-FMAU), from L-arabinose, wherein: X is a halogen; and B is a pyrimidine, purine, heterocyclic or heteroaromatic base. Compounds of formula I have been found to be useful in the inhibition of viral DNA synthesis at the triphosphate level, probably by tight binding to viral polymerase.
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