Use of non-antibacterial tetracycline analogs and formulations thereof for the treatment of bacterial exotoxins

摘要

Described is the use of a non-bacterial tetracycline in the manufacture of a medicament for protecting a mammal at risk of acquiring a condition associated with bacteria that produce a calmodulin exotoxin, a metalloproteinase exotoxin, or both. The bacteria is selected from the group consisting of Bacillus anthracis, Clostridium perfringens, Bordetella pertussis, Bacteriodes fragilis, or Pseudomonas aeruginosa. The tetracycline is selected from CMT-1, CMT-2, CMT-4, CMT-6, CMT-7 or CMT-9.