发明名称 |
Therapeutic drug using antibody-presenting hollow protein nanoparticles and hollow protein nanoparticles |
摘要 |
The invention provides a therapeutic drug that uses hollow protein nanoparticles displaying an antibody against a specific cell or specific tissue. The effectiveness of the drug has been proved by animal testing. The invention also provides a therapeutic method using such a drug. In a drug according to the present invention, a substance to be transferred into a cell for treating a disease (for example, a cancer treating gene such as a thymidine kinase gene derived from simple herpes virus) is encapsulated in hollow nanoparticles of a particle-forming protein (for example, hepatitis B virus surface-antigen protein that has been modified to lack its infectivity to hepatocytes and display an antibody). The particle surface of the drug displays an antibody, such as a cancer specific antibody, that recognizes an antigen molecule displayed on the surface of a specific cancer cell.
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申请公布号 |
US2006088536(A1) |
申请公布日期 |
2006.04.27 |
申请号 |
US20030509249 |
申请日期 |
2003.03.26 |
申请人 |
KURODA SHUNICHI;TANIZAWA KATSUYUKI;OKAJIMA TOSHIHIDE;KONDO AKIHIKO;UEDA MASAKAZU;SENO MASAHARU |
发明人 |
KURODA SHUNICHI;TANIZAWA KATSUYUKI;OKAJIMA TOSHIHIDE;KONDO AKIHIKO;UEDA MASAKAZU;SENO MASAHARU |
分类号 |
A61K39/395;C12N15/09;A61K9/14;A61K9/50;A61K9/51;A61K39/245;A61K39/29;A61K39/42;A61K47/48;A61K48/00;A61P35/00;C07K14/02;C07K16/18;C07K16/28;C07K16/40;C12N7/04;C12N15/88 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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