The present invention relates to methods and compositions for use in mediating an immunosuppressive reaction. The compositions of the invention comprise exosomes having immunosuppressive activity. Such exosomes may be derived from a variety of different cell types, including antigen presenting cells such as dendritic cells and macrophages. Prior to isolation of exosomes, the cells may be genetically engineered to express molecules capable of enhancing the immunosuppressive activity of said exosomes and/or may be exposed to one or more agents, such as cytokines or cytokine inhibitors, which are also capable of enhancing the immunosuppressive activity of exosomes. The present invention also relates to the use of such exosomes for the treatment of diseases and disorders associated with undesirable activation of the immune system. The present invention also includes exosomes isolated directly from serum that have been shown to be immunosuppressive.
申请公布号
WO2006007529(A9)
申请公布日期
2006.04.27
申请号
WO2005US23336
申请日期
2005.07.01
申请人
M FOR HIGHER EDUCATION UNIVERSITY OF PITTSBURGH OF THE COMMONWEALTH SYSTE;ROBBINS, PAUL, D.;KIM, SEON-HEE;WEHLING, PETER