| 摘要 |
The present invention refers to coumarin ethers of the formula (I), wherein R<SUP>1</SUP> is H, OH or (E)-3-methyl-but-2-enyl, R<SUP>2</SUP> is selected from the group consisting of methyl, 3-(4,5-dihydro-5,5-dimethyl-4-furanon-2-yl)-2-(E/Z)-butenyl, (E/Z)-3,7-dimethylocta-2,6-dienyl, 7-hydroxy-3,7-dimethyl-2-octen-6-on-yl and (E/Z,E/Z)-11-acetyl-oxy-3,7,11,11-tetramethyl-undeca-2,7-dien-10-on-yl, R<SUP>3</SUP> is H, R<SUP>1</SUP> and R<SUP>2</SUP>O together for the group -O-C(C(=CH<SUB>2</SUB>)CH<SUB>3</SUB>)H-CH<SUB>2</SUB>-O- or the group -C(H)=C(H)-C(CH<SUB>3</SUB>)<SUB>2</SUB>-O- or R<SUP>2</SUP>O and R<SUP>3</SUP> together form the group -O-C(H)(C(CH<SUB>3</SUB>)<SUB>2</SUB>(H)-O-C(O)CH<SUB>3</SUB>)-CH<SUB>2</SUB>-, preferably to obliquin, for use as medicaments, especially for the treatment and/or prevention of disorders connected to impaired neurotransmission, as well as to dietary and pharmaceutical compositions and plant extracts containing such coumarin ethers and their uses. |
| 申请人 |
DSM IP ASSETS B.V.;DE SAIZIEU, ANTOINE;FOWLER, ANN;GORALCZYK, REGINA;MUSSLER, BERND;SCHUELER, GOEDE |
发明人 |
DE SAIZIEU, ANTOINE;FOWLER, ANN;GORALCZYK, REGINA;MUSSLER, BERND;SCHUELER, GOEDE |
