| 摘要 |
The invention relates to the use of memantine (chlorhydrate of 1-amino-3,5-dimethyl-adamantane) to prevent against adverse neurotoxic reactions caused by antileukemic chemotherapy, primarily in treatment schemes that include cytosine arabinoside (Ara-C or cytarabine), vincristine and/or L-asparaginase. The invention aims to satisfy the growing need for strategies that improve the effectiveness of anticancer treatments, by increasing the survival of patients affected and/or improving quality of life. Despite the fact that antileukemic treatment causes severe damage to the nervous system, there is currently no specific treatment intended to prevent said alterations which can sometimes be permanent or fatal.
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