1-[2-(4-BENZYL-4-HYDROXY-PIPERIDIN-1-YL)-ETHYL]-3-(2-METHYL-QUINOLIN-4-YL)-UREA SALT

摘要

PROBLEM TO BE SOLVED: To improve the instability and low biological effects during storage of 1-[2-(4-benzyl-4-hydroxy-piperidin-1-yl)-ethyl]-3-(2-methyl-quinolin-4-yl)-urea as a free base. SOLUTION: The 1-[2-(4-benzyl-4-hydroxy-piperidin-1-yl)-ethyl]-3-(2-methyl-quinolin-4-yl)-urea is converted into a crystalline salt or a non-crystalline salt hydrate with sulfuric acid, malic acid or citric acid. Furthermore, a method for producing the crystalline salt or non-crystalline salt hydrate is provided. The use of the crystalline salt or non-crystalline salt hydrate alone or in combination with other compounds for treatment of various diseases associated with dysregulation of urotensin II or urotensin II receptors or the use of the crystalline salt or non-crystalline salt hydrate in the preparation of pharmaceutical compositions is provided. COPYRIGHT: (C)2006,JPO&NCIPI