METHODS FOR DIAGNOSING BIPOLAR AND UNIPOLAR DISORDER
摘要
Changes that occur in Na<SUP>+</SUP>K<SUP>+</SUP> ATPase regulation and therefore in the membrane potential in cells from bipolar individuals, as compared to cells from unaffected control individuals, are utilized to provide a diagnostic assay for bipolar disorder. The diagnostic assay may also or instead exploit the similarity of cells from bipolar patients to those of people already known to have bipolar disorder. A similar diagnostic assay is provided for diagnosing unipolar disorder. The diagnostic assays may further involve manipulation of membrane potential by incubation of cells in K<SUP>+</SUP>-free buffer and/or incubation with one or more compounds that alter Na<SUP>+</SUP>K<SUP>+</SUP> ATPase activity. Although a variety of cells may be used, the diagnostic assays preferably employ lymphoblasts or whole blood cells.
申请公布号
WO2005045057(A3)
申请公布日期
2006.04.27
申请号
WO2004US32766
申请日期
2004.10.26
申请人
FREE STATE DIAGNOSTICS, INC.;THIRUVENGADAM, ALAGU, P.;CHANDRASEKARAN, KRISH;REGENOLD, WILLIAM, T.
发明人
THIRUVENGADAM, ALAGU, P.;CHANDRASEKARAN, KRISH;REGENOLD, WILLIAM, T.