Heterocyclic compounds useful as nurr-1 activators

摘要

The present invention relates to compounds of formula (I): wherein R₁ is hydroxy, C_1-4 alkoxy, amino, C_1-4 alkyl-amino, di C_1-4alkylamino, benzyloxy or C₂-C₇ alkanoyl, R₂ is C_1-4 alkyl, C_1-4 alkoxy, C_1-4 alkoxy C_1-4alkoxy, CF₃, halogen, C_1-4alkylamino, di C_1-4alkylamino, di C_1-4 alkylamino C_1-4 alkoxy or N-C_1-4 alkoxy C_1-4 alkyl-N-C_1-4 alkylamino, N-C_1-4 alkyl-piperazinyl, morpholinyl or pyrrolidinyl-C_1-4 alkoxy, wherein the C_1-4 alkyl radicals in R₂ are optionally further substituted by C_1-4 alkyl, halogen, cyano, amino, alkoxy or alkylthio, X is N or O, Y is N, O or CH, Z is N or CH, and W is N or CH, provided that (a) R₁ is not hydroxy or C_1-4 alkoxy when R₂ is CF₃, X is O, Y is CH, Z is N and W is CH, (b) R₁ is not hydroxy or C_1-4 alkoxy when R₂ is CF₃ or chloro, X is N, Y is O, Z is CH and W is CH, (c) R₁ is not hydroxy when R₂ is CF₃, X is O, Y is N, Z is CH and W is CH and (d) X and Y are not simultaneously O, the salts thereof; their preparation, their use and pharmaceutical compositions containing them.