Modulators of Rho C activity

摘要

Compounds of formula 1 modulate the activity of Rho C: wherein R₁ is H, lower alkyl, aralkyl, aryl-lower alkenyl, or -(CH₂)_nCH(R₇)NR₈R₉, where n is 0-6 inclusive, R₇ is H, lower alkyl, aryl, or aralkyl, R₈ is H, lower alkyl, cyclo-alkyl, aryl, or aralkyl, and R₉ is R, RCO-, ROCO-, or RNHCO-, where R is lower alkyl, cycloalkyl, aryl, or aralkyl, wherein aryl and aralkyl are substituted with 0-3 substituents selected from the group consisting of lower alkyl, halo, nitro, -OH, trifluoromethyl, or lower alkoxy; R₂ is lower alkyl, aryl, aralkyl, or -(CHR₁₀)_m-(CO)-R₁₁, wherein m is 0-4, R₁₀ is H or lower alkyl, and R₁₁ is lower alkyl, cycloalkyl, aryl, or aralkyl, wherein aryl and aralkyl are substituted with 0-3 substituents selected from the group consisting of lower alkyl, halo, nitro, -OH, trifluoromethyl, or lower alkoxy; R₃, R₄, R₅, and R₆, are each independently H, lower alkyl, halo, nitro, OH, lower alkoxy, NH₂, lower alkylamino, di(lower alkylamino), trifluoromethyl, or SH; or a pharmaceutically acceptable salt thereof.