发明名称 Nucleic acids and polypeptides which resemble Rho and which interact with cell signalling pathways and proteins
摘要 The present invention relates to an isolated full-length Chp polypeptide, a biologically-active polypeptide fragment thereof, and nucleic acids which code for it. This polypeptide has various activities in regulating cell signaling and signal transduction pathways, including, e.g., a PAK regulatory domain binding activity, a PAK kinase stimulatory activity, a JNK kinase stimulatory activity, a cytoskeletal-reorganizing activity, or a Chp-specific immunogenic activity. The invention relates to all aspects of Chp, or homologs thereof, including assays for modulators, activators, ligands, etc.
申请公布号 US7442534(B2) 申请公布日期 2008.10.28
申请号 US20020330372 申请日期 2002.12.27
申请人 ONYX PHARMACEUTICALS, INC. 发明人 ABO ARIE;ARONHEIM AMI
分类号 C12N9/14;C12N15/09;A61K39/395;C07K14/47;C07K16/18;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N9/16;C12N15/55;C12P21/02;C12Q1/02;C12Q1/48;C12Q1/68 主分类号 C12N9/14
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