发明名称 |
Universal peptide-binding scaffolds and protein chips |
摘要 |
The present invention provides a universal peptide-binding scaffold. This scaffold is used to bind a target. The target can be a peptide or peptides of interest (for example, peptides associated with a disease state) or can represent the entire proteome. The target can be either protein fragments prepared by enzymatic digestion of the entire proteome or N- or C-terminal short sequences exposed by chemical denaturation of the entire proteome (unfolded proteins). The universal peptide-binding scaffold can be tailored to specifically bind a target using the methods described herein.
|
申请公布号 |
US7442773(B2) |
申请公布日期 |
2008.10.28 |
申请号 |
US20050040686 |
申请日期 |
2005.01.21 |
申请人 |
THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS |
发明人 |
ZHAO HUIMIN;ESTEBAN OLGA |
分类号 |
C07K16/00;C07K14/74;C12N1/00;C40B20/02;C40B30/04;C40B40/02;C40B40/10;G01N33/53;G01N33/543;G01N33/68 |
主分类号 |
C07K16/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|