发明名称 Indanyl-piperazine compounds
摘要 A compound selected from those of formula (I): wherein: R<SUB>3 </SUB>represents a hydrogen atom, and R<SUB>1 </SUB>and R<SUB>2 </SUB>together with the carbon atoms carrying them form a benzene, naphthalene or quinoline ring structure, each of the ring structures being optionally substituted, or R<SUB>1 </SUB>represents a hydrogen atom, and R<SUB>2 </SUB>and R<SUB>3 </SUB>together with the carbon atoms carrying them form a benzene, naphthalene or quinoline ring structure, each of the ring structures being optionally substituted, n represents 1 or 2, -X- represents a group selected from -(CH<SUB>2</SUB>)<SUB>m</SUB>-O-Ak-, -(CH<SUB>2</SUB>)<SUB>m</SUB>-NR<SUB>4</SUB>-Ak-, -(CO)-NR<SUB>4</SUB>-Ak- and -(CH<SUB>2</SUB>)<SUB>m</SUB>-NR<SUB>4</SUB>-(CO)-, m represents an integer between 1 and 6 inclusive, Ak represents an optionally substituted alkylene chain, and R<SUB>4 </SUB>represents a hydrogen atom or an alkyl group, Ar represents an aryl or heteroaryl group, its enantiomers, diasteroisomers, and addition salts thereof with a pharmaceutically acceptable acid. Medical products containing the same which are useful in the treatment of conditions requiring a serotonin reuptake inhibitor and/or NK<SUB>1 </SUB>antagonist.
申请公布号 US7442692(B2) 申请公布日期 2008.10.28
申请号 US20060391916 申请日期 2006.03.29
申请人 LES LABORATOIRES SERVIER 发明人 DE NANTEUIL GUILLAUME;PORTEVIN BERNARD;GLOANEC PHILIPPE;MILLAN MARK;ORTUNO JEAN-CLAUDE;LA COUR CLOTILDE MANNOURY;GOBERT ALAIN
分类号 A61K31/551;A61K31/495;A61K31/496;C07D295/084;C07D295/125;C07D295/145 主分类号 A61K31/551
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