发明名称 |
Polymorphic forms of sertraline hydrochloride |
摘要 |
Sertraline hydrochloride polymorphic form II is conveniently prepared by adding hydrogen chloride to solution of sertraline free amine in a ketone. In preferred processes, the solution of sertraline free amine seeded with some crystals of polymorphic form II and/or the solution is heated before addition of the hydrogen chloride.
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申请公布号 |
US7442838(B2) |
申请公布日期 |
2008.10.28 |
申请号 |
US20050101860 |
申请日期 |
2005.04.08 |
申请人 |
CIBA SPECIALTY CHEMICALS CORP. |
发明人 |
VAN DER SCHAAF PAUL ADRIAAN;SCHWARZENBACH FRANZ;KIRNER HANS JUERG;SZELAGIEWICZ MARTIN;MARCOLLI CLAUDIA;BURKHARD ANDREAS |
分类号 |
C07C211/42;A61K31/135;A61K31/137 |
主分类号 |
C07C211/42 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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