发明名称 |
Ligand activated transcriptional regulator proteins |
摘要 |
Fusion proteins for use as ligand-dependent transcriptional regulators are provided. The fusion proteins include a nucleotide binding domain operatively linked to a ligand-binding domain. They also can include a transcription regulating domain. The nucleotide binding domain is a zinc-finger peptide that binds to a targeted contiguous nucleotide sequence of from 3 to about 18 nucleotides are provided. The fusion proteins are used for gene therapy. Also provided are polynucleotides encoding the fusion proteins, expression vectors, and transfected cells.
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申请公布号 |
US7442784(B2) |
申请公布日期 |
2008.10.28 |
申请号 |
US20030422934 |
申请日期 |
2003.04.23 |
申请人 |
THE SCRIPPS RESEARCH INSTITUTE;NOVARTIS AG |
发明人 |
BARBAS, III CARLOS F.;KADAN MICHAEL JOSEPH;BEERLI ROGER |
分类号 |
C07H21/04;C12N15/09;A61K9/127;A61K35/76;A61K38/00;A61K48/00;A61P35/00;A61P43/00;C07K14/47;C07K14/705;C07K14/72;C07K19/00;C12N1/15;C12N1/19;C12N5/00;C12N5/02;C12N5/10;C12N15/00;C12N15/63;C12P21/04;C12P21/06 |
主分类号 |
C07H21/04 |
代理机构 |
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代理人 |
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地址 |
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