发明名称 |
PYRROLE DERIVATIVE OR SALT THEREOF. |
摘要 |
<p>[PROBLEMS] To provide a compound which can be used for the prevention and/or treatment of a disease associated with a 5-HT2B receptor or a 5-HT7 receptor, particularly for the treatment of irritable bowel syndrome (IBS). [MEANS FOR SOLVING PROBLEMS] It is found that a pyrrole derivative having a guanidinocarbonyl group or an amide group at position-3 as a substituent or a pharmaceutically acceptable salt thereof has a potent antagonistic effect on both of a 5-HT2B receptor and a 5-HT7 receptor. The compound shows a better pharmacological activity compared to an antagonist which is selective to either of these receptors. Therefore, the compound is useful for the prevention and/or treatment of a disease associated with a 5-HT2B receptor or a 5-HT7 receptor, particularly for the treatment of irritable bowel syndrome (IBS).</p> |
申请公布号 |
MX2008010644(A) |
申请公布日期 |
2008.10.28 |
申请号 |
MX20080010644 |
申请日期 |
2007.02.19 |
申请人 |
ASTELLAS PHARMA INC. |
发明人 |
DAISUKE KAGA;HIROYOSHI YAMADA;SHINOBU AKUZAWA;RYUSHI SEO;HIDETAKA KAKU |
分类号 |
C07D207/34;A61K31/40;A61K31/4025;A61K31/404;A61K31/422;A61K31/433;A61K31/439;A61K31/454;A61K31/4725;A61P1/00;A61P43/00;C07D401/04;C07D401/10;C07D403/04;C07D407/04;C07D409/04;C07D409/12;C07D413/04;C07D417/04;C07D453/02 |
主分类号 |
C07D207/34 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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