发明名称 |
PROCESSES TO GENERATE SUBMICRON PARTICLES OF WATER-INSOLUBLECOMPOUNDS |
摘要 |
Submicron particles of water-insoluble compounds, particularly drugs, are prepared by simultaneously stabilizing microparticulate suspensions of same with surface modifier molecules by rapid expansion into an aqueous medium from a compressed solution of the compound and surface modifiers in a liquefied gas and optionally homogenizin g the aqueous suspension thus formed with a high pressure homogenizer.
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申请公布号 |
CA2335472(C) |
申请公布日期 |
2008.10.28 |
申请号 |
CA19992335472 |
申请日期 |
1999.06.18 |
申请人 |
RTP PHARMA INC. |
发明人 |
PACE, GARY W.;KRUKONIS, VAL;GUDINAS, ANTHONY;HENRIKSEN, INGE B.;MISHRA, AWADHESH K.;VACHON, MICHAEL G. |
分类号 |
A61K9/10;A61K9/14;A61K9/16;A61K9/51;A61K31/216;A61K31/57;A61K31/573;A61K38/00;A61K38/13;A61K47/24;A61K47/34;B01F3/12;B01J3/00 |
主分类号 |
A61K9/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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