| 发明名称 |
CHEMOKINE RECEPTOR BINDING HETEROCYCLIC COMPOUNDS WITH ENHANCED EFFICACY |
| 摘要 |
The invention relates to heterocyclic compounds consisting of a core nitrogen atom surrounded by three pendant groups, wherein two of the three pendant groups are preferably benzimidazolyl methyl and tetrahydroquinolyl, and the third pendant group contains N and optionally contains additional rings. The compounds bind to chemokine receptors, including CXCR4 and CCR5, and demonstrate protective effects against infection of target cells by a human immunodeficiency virus (HIV).
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| 申请公布号 |
US2008167341(A1) |
申请公布日期 |
2008.07.10 |
| 申请号 |
US20080036187 |
申请日期 |
2008.02.22 |
| 申请人 |
BRIDGER GARY;SKERLJ RENATO T;KALLER AL;HARWIG CURTIS;BOGUCKI DAVID;WILSON TREVOR R;CRAWFORD JASON B;MCEACHERN ERNEST J;ATSMA BEM;NAN SIQIAO;ZHOU YUANXI;SCHOLS DOMINIQUE;SMITH CHRISTOPHER DENNIS;DI FLURI MARIA R |
发明人 |
BRIDGER GARY;SKERLJ RENATO T.;KALLER AL;HARWIG CURTIS;BOGUCKI DAVID;WILSON TREVOR R.;CRAWFORD JASON B.;MCEACHERN ERNEST J.;ATSMA BEM;NAN SIQIAO;ZHOU YUANXI;SCHOLS DOMINIQUE;SMITH CHRISTOPHER DENNIS;DI FLURI MARIA R. |
| 分类号 |
A61K31/4709;A01N43/42;A01N43/50;A01N43/52;A01N43/58;A01N43/60;A61K31/415;A61K31/47;A61K31/495;A61K31/50;A61P7/00;C07D235/10;C07D235/14;C07D401/12;C07D401/14;C07D403/12;C07D471/04;C07D471/06;C07D491/04;C12N |
主分类号 |
A61K31/4709 |
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