发明名称 |
Inhibition of osteopontin for treatment of relapsing autoimmune disease |
摘要 |
Methods are provided for the inhibition or prevention of relapses in pre-existing autoimmune disease by decreasing activity or expression of osteopontin in immune cells found in tissues affected by the autoimmune disease. Osteopontin is shown herein to mediate autoimmune relapses and induce a shift to the secondary or progressive stage in autoimmune disease. Osteopontin promotes the survival of activated T cells through regulation of transcription factors, FoxO3a and NF-kappaB and via the expression of pro-apoptotic proteins.
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申请公布号 |
US2008166339(A1) |
申请公布日期 |
2008.07.10 |
申请号 |
US20070999099 |
申请日期 |
2007.12.03 |
申请人 |
YOUSSEF SAWSAN;HUR EUN MI;STEINMAN LAWRENCE |
发明人 |
YOUSSEF SAWSAN;HUR EUN MI;STEINMAN LAWRENCE |
分类号 |
A61K39/395;A61K31/70;A61P37/00 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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