发明名称 |
HYDROPHILIC POLYMER-CONJUGATED LIPIDS FOR PEPTIDE AND PROTEIN FOLDING DISORDERS |
摘要 |
The present invention provides a method of correcting peptide or protein misfolding, which can be used to treat peptide and protein disorder in a mammalian subject. The method comprises administering to the mammalian subject, preferably a human subject, an effective amount of a composition comprising sterically stabilized simple micelles (SSM) of a hydrophilic polymer-conjugated lipid or sterically stabilized mixed micelles (SSMM) of a hydrophilic polymer-conjugated lipid and a water-insoluble lipid. The composition may further comprise a biologically active compound, such as but not limited to vasoactive intestinal peptide (VIP), associated with the SSM or SSMM. |
申请公布号 |
WO2008054498(A3) |
申请公布日期 |
2008.07.10 |
申请号 |
WO2007US08660 |
申请日期 |
2007.04.06 |
申请人 |
THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS;ONYUKSEL, HAYAT;RUBINSTEIN, ISRAEL |
发明人 |
ONYUKSEL, HAYAT;RUBINSTEIN, ISRAEL |
分类号 |
A61K47/48 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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