| 摘要 |
The present invention relates to methods of synthesizing anthracycline derivatives. Among other advantages, these methods offer simple and efficient manipulation of substituents on the sugar ring of anthracyclines. For example, the C-3 ' amino of such sugars may be protected such that alkylation of hydroxy positions, such as a C-4' hydroxy, may be regioselectively performed. These methods allow access to a variety of anthracycline derivatives, which may show antibiotic and/or anticancer activity. |
