摘要 |
<p>A quinolone synthetic antibacterial agent having excellent properties as a medicine is provided, which has strong antibacterial activity not only to Gram-negative bacteria but also to Gram-positive cocci that have low sensiti vity to quinolone antibacterial agents, and which exhibits high safety and e xcellent pharmacokinetics. A compound represented by the formula (I) or a sa lt thereof, or a hydrate thereof. Specifically, a quinolone derivative of th e formula (I) wherein substituents R6 and R7 taken together with the carbon atoms to which they are bonded form a cyclic structure which may contain an oxygen atom as a ring constituent atom, the cyclic structure forming a 5-4, 5-5, or 5-6 fused bicyclic pyrrolidinyl substituent, the substituent being b onded to a quinolone mother skeleton Q containing a pyridobenzoxazine struct ure.</p> |
申请人 |
DAIICHI SANKYO COMPANY, LIMITED |
发明人 |
NAGAMOCHI, MASATOSHI;MIYAUCHI, RIE;NAKAYAMA, KIYOSHI;TAKEMURA, MAKOTO;TSUDA, TOSHIFUMI;KOMORIYA, SATOSHI;YOSHIDA, KENICHI;TAKAHASHI, HISASHI;ODAGIRI, TAKASHI;INAGAKI, HIROAKI;KITAMURA, TAKAHIRO |