METHODS FOR ENHANCING EXERCISE PERFORMANCE

摘要

Disclosed herein are methods for enhancing one or more effects of exercise in a subject by administering a PPARd agonist {e.g., GW1516) to the subject in combination with an exercise program. Also disclosed are gene expression profiles unique to the combination of agonist-induced PPARd activation and exercise. Such profiles are useful, at least, in methods for identifying the use of performance-enhancing drugs in exercised subjects (such as, professional or athletes). Direct interactions between PPARd and exercised-induced kinases {e.g., AMPK or its subunits, AMPK al and/or AMPK a2) also are disclosed. Such protein-protein interactions provide new targets for identification of useful compounds.